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KMID : 1007520140230020641
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Food Science and Biotechnology
2014 Volume.23 No. 2 p.641 ~ p.646
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Trans Vaccenic Acid (trans-11 18:1), a Precursor of Cis-9, Trans-11- Conjugated Linoleic Acid, Exerts a Direct Anti-carcinogenic Function in T47D Breast Carcinoma Cells
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Oh Jin-Ju
Lee Jae-Sung
Lim Ji-Na
Wang Tao
Kim Sang-hun
Lee Hong-Gu
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Abstract
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The role of TVA in suppressing proliferation of various human cancer cell lines was investigated that TVA and c9, t11-CLA both suppressed cell proliferation. The suppressive effect of TVA was clearly observed in T47D breast carcinoma cells after stearoyl-CoA desaturase-1 (SCD) knockdown using small interfering RNA (siRNA), demonstrating TVA directly affects suppression of human breast carcinogenesis.
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KEYWORD
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cis-9, trans-11-conjugated linoleic acid, enzyme delta 9 desaturase, small interfering RNA, T47D breast carcinoma cell, trans-11 18:1 vaccenic acid
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